How does the pre-frontal cortex affect behavior?

The frontal lobe is the seat of motor planning and control, parts of the working memory, and the control of personality. Information from other cortical areas is taken into account: seeing, hearing, feeling, memory of previous experiences. The frontal lobe exchanges with the limbic system: While this generates emotions, the frontal lobe enables them to be controlled.

The motor (Broca'sche) language center (area 44/45) borders on premotor areas and the anterior central turn (areas for face, throat and larynx). It manages motor skills and meaning analysis in the context of language processing. In ~ 95% of right-handed, including the majority of left-handed people, the motor language center is located in the left cerebral hemisphere ("language-dominant" hemisphere), sometimes the language center is also bilateral.

The prefrontal brain - the anterior part of the frontal lobe - takes current sensory information into account with regard to appropriate behavioral patterns (analysis and monitoring system): It organizes behavior in the sense of a rational control instance (control of emotional impulses from the limbic system). Its afferents come not only from the (mediodorsal) thalamus (glutamatergic), but also from the brain stem (dopaminergic, noradrenergic, serotoninergic) and diencephalon (cholinergic, GABAerg).

The orbital prefrontal cortex can generate feelings of happiness and fear - with its connections to the amygdala and island, it controls the "emotional personality".